Publications


THE JOURNAL OF THE PALO ALTO INSTITUTE

Want to be published in our quarterly journal? Send submissions to info@paloaltoinstitute.org

 

 

VOL. 12, February 2013

Does Chronic Consumption of Stimulants Induce Vagal Bias? – Joon Yun
Hard-wired for a High-stakes Past, but Now Living in a Low-Stakes World – Joon Yun

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VOL. 11, January 2013

Healthcare is a Natural Hedge for Pension Funds – Joon Yun
Vagal Bias and the Common Cold – Joon Yun
Hospital, heal thyself. – Joon Yun
Thinking About Design – Joon Yun

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VOL. 10, December 2012

Lemmings and Ostriches – Joon Yun
Stress is the Mechanism by Which Food Causes Human Disease – Joon Yun

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VOL. 9, October 2012

Another Golden Age of Growth Investing – Joon Yun

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VOL. 8, July 2012

Xenovation: Innovation from the Outside In – Joon Yun
The Depopulation Portfolio – Joon Yun

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VOL. 7, July 2012

Brief History of Biologic Innovation – Joon Yun
The Grand Bargain – Joon Yun

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VOL. 6, June 2012

Twenty Blinks – Joon Yun
Keep the Buck:  The Rational Basis of Irrational Exuberance – Joon Yun
Relationship Liquidity – Joon Yun

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VOL. 5, February 2012

Future of Human Evolution – Joon Yun
Status Update – Joon Yun
Food Allergy, Asthma, Anaphylaxis, and Autonomic Dysfunction – Joon Yun, Charlie Cho
10x – Joon Yun
Therapeutics as the Next Frontier in the Evolution of Darwinian Medicine – Joon Yun

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VOL. 4, January 2012

Curate – Joon Yun
Caffeine and the Age of Enlightenment – Joon Yun
Ethylene: the Most Important Molecule You've Never Heard Of? – Joon Yun
Darwinian Rubbernecking – Joon Yun

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VOL. 3, NO. 1, Fall 2011

Reverse Malthus – Joon Yun
Freedom and Population Density – Joon Yun
Empathy: It's Not You, It's Me – Joon Yun

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VOL. 2, NO. 1, Summer 2010

Hiding in Plain Sight – Joon Yun
Three Secrets to a Funnier You – Joon Yun
Has Death Outlived its Usefulness – Joon Yun

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VOL. 1, NO. 1, Summer 2009

Compound Thinking – Joon Yun
Price and Money: Wag the Dog – Joon Yun
A Balanced Diet – Joon Yun

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ARTICLES

We're proud to publish a wide range of thinking and perspective - following are some recent publications from the PAI Archive.

MODULATION OF AUTONOMIC BALANCE BY TUMORS AND VIRUSES
Anthony J. Yun, Patrick Y. Lee
Medical Hypotheses Journal, 2004
(download)

 

TEMPORAL VARIATION OF AUTONOMIC BALANCE AND DISEASES DURING CIRCADIAN, SEASONAL, REPRODUCTIVE, AND LIFESPAN CYCLES
Anthony J. Yun, Patrick Y. Lee
Medical Hypotheses Journal, 2004
(download)

 

THE HEGEMONY OF EMPIRICISM: THE OPPORTUNITY FOR THEORETICAL SCIENCE IN MEDICINE
Anthony J. Yun
Medical Hypotheses Journal, 2008
(download)

 

UNHAPPY MEAL: HOW OUR NEED TO DETECT STRESS MAY HAVE SHAPED OUR PREFERENCES FOR TASTE
Anthony J. Yun, John D. Doux
Medical Hypotheses Journal, February 2007
(download)

 

IS ATHEROSCLEROSIS A NEUOGENIC PHENOMENON?
Rakesh S. Marwah, John D. Doux, Patrick Y. Lee, Anthony J. Yun
Medical Hypotheses Journal, January 2007
(download)

 

STRESS DYSFUNCTIONS AS A UNIFYING PARADIGM FOR ILLNESS: REPAIRING RELATIONSHIPS INSTEAD OF INDIVIDUALS AS A NEW GATEWAY FOR MEDICINE
Anthony J. Yun, John D. Doux
Medical Hypotheses Journal, August 2006
(download)

 

PERIPHERAL ARTERIAL DISEASE: A MANIFESTATION OF EVOLUTIONARY DISLOCATION AND FEED-FORWARD DYSFUNCTION
John D. Simpson, John D. Doux, Patrick Y. Lee, Anthony J. Yun
Medical Hypotheses Journal, March 2006
(download)

 

A PARADIGM FOR VIEWING BIOLOGIC SYSTEMS AS SCALE-FREE NETWORKS
Anthony J. Yun, Patrick Y. Lee, John D. Doux
Medical Hypotheses Journal, February 2006
(download)

 

EFFICIENT INEFFICIENCY
Anthony J. Yun, Patrick Y. Lee, John D. Doux
Medical Hypotheses Journal, February 2006
(download)

 

OSTEOARTHRITIS: AN EXAMPLE OF PHENOPTOSIS THROUGH AUTONOMIC DYSFUNCTION?
Anthony J. Yun, Patrick Y. Lee, John D. Doux
Medical Hypotheses Journal, February 2006
(download)

 

BREWING CONTROVERSIES: DARWINIAN PERSPECTIVE ON THE ADAPTIVE AND MALADAPTIVE EFFECTS OF CAFFEINE AND ETHANOL AS DIETARY AUTONOMIC MODULATORS
Anthony J. Yun, John D. Doux, Stephanie M. Daniel
Medical Hypotheses Journal, January 2006
(download)

 

PARADOXICAL INFLAMMATION REVISITED: MURAGLITAZAR AND CARDIOVASCULAR RISK
Anthony J. Yun, Patrick Y. Lee, John D. Doux
Medical Hypotheses Journal, 2006
(download)

 

SALMETEROL AND PAROXETINE: MORE EVIDENCE FOR PARADOXICAL MEDICINE
Anthony J. Yun, Patrick Y. Lee
Medical Hypotheses Journal, 2006
(download)

 

OPENING THE FLOODGATES
Anthony J. Yun, John D. Doux
Medical Hypotheses Journal, December 2005
(download)

 

A NEW WRINKLE
Kimberly A. Bazar, John D. Doux, Anthony J. Yun
Medical Hypotheses Journal, December 2005
(download)

 

WHEN NORMAL IS NOT: THE DILEMMA OF INTERPRETING LABORATORY AVERAGES OF BIOACTIVE MOLECULES SUBJECT TO HETEROGENEOUS REGULATORY FEEDBACK AND EPIGENETIC MOSAICISM
John D. Doux, Anthony J. Yun
Medical Hypotheses Journal, November 2005
(download)

 

ENVIRONMENTAL DISCONTINUITY HYPOTHESIS: BUFFER DYSFUNCTIONS AS A SOURCE OF HUMAN DISEASE
Anthony J. Yun
Medical Hypotheses Journal, November 2005
(download)

 

ARE WE EATING MORE THAN WE THINK?
Anthony J. Yun, Patrick Y. Lee, John D. Doux
Medical Hypotheses Journal, November 2005
(download)

 

CONTRAST NEPHROPATHY MAY BE PARTLY MEDIATED BY AUTONOMIC DYSFUNCTION
Anthony J. Yun, John D. Doux, Patrick Y. Lee
Medical Hypotheses Journal, October 2005
(download)

 

A GENERAL THEORY OF EVOLUTION BASED ON ENERGY EFFICIENCY: ITS IMPLICATIONS FOR DISEASES
Joon Yun, Patrick Y. Lee, John D. Doux, Buford R. Conley
Medical Hypotheses Journal, July 2005
(download)

 

THE LINK BETWEEN CAROTID ARTERY DISEASE AND ISCHEMIC STROKE
John D. Doux, Anthony J. Yun
Medical Hypotheses Journal, March 2005
(download)

 

INTEGRATING THE THEORIES OF DARWIN AND BERNOULLI
Buford R. Conley, John D. Doux, Patrick Y. Lee, Kimberly A. Bazar, Stephanie M. Daniel, Anthony J. Yun
Medical Hypotheses Journal, March 2005
(download)

 

SYMPATHETIC AND T HELPER (TH)2 BIAS MAY AMELIORATE UTERINE FIBROIDS, INDEPENDENT OF SEX STEROIDS
Anthony J. Yun, Stephanie M. Daniel
Medical Hypotheses Journal, March 2005
(download)

 

THE INCORPORATION OF IODINE IN THYROID HORMONE MAY STEM FROM ITS ROLE AS A PREHISTORIC SIGNAL OF ECOLOGIC OPPORTUNITY
Anthony J. Yun, Patrick Y. Lee, Kimberly A. Bazar, Stephanie M. Daniel, John D. Doux
Medical Hypotheses Journal, February 2005
(download)

 

ADVENTITIAL DYSFUNCTION: AN EVOLUTIONARY MODEL FOR UNDERSTANDING ATHEROSCLEROSIS
Anthony J. Yun, John D. Doux, Kimberly A. Bazar, Patrick Y. Lee
Medical Hypotheses Journal, February 2005
(download)

 

OBESITY AND ADHD MAY REPRESENT DIFFERENT MANIFESTATIONS OF A COMMON ENVIRONMENTAL OVERSAMPLING SYNDROME
Kimberly A. Bazar, Anthony J. Yun, Patrick Y. Lee, Stephanie M. Daniel, John D. Doux
Medical Hypotheses Journal, February 2005
(download)

 

THE LINK BETWEEN T HELPER BALANCE AND LYMPHOPROLIFERATIVE DISEASE
Anthony J. Yun, Patrick Y. Lee
Medical Hypotheses Journal, January 2005
(download)

 

THE INTELLECTUAL LINEAGE OF PARADOXICAL PHARMACOLOGY STRATEGY
Anthony J. Yun
Medical Hypotheses Journal, 2005
(download)

 

CAN CHRONIC USE OF ANTI-INFLAMMATORY AGENTS PARADOXICALLY PROMOTE CHRONIC INFLAMMATION THROUGH COMPENSATORY HOST RESPONSE?
John D. Doux, Kimberly A. Bazar, Patrick Y. Lee, Anthony J. Yun
Medical Hypotheses Journal, December 2004
(download)

 

THE SMOKING GUN: MANY CONDITIONS ASSOCIATED WITH TOBACCO EXPOSURE MAY BE ATTRIBUTABLE TO PARADOXICAL COMPENSATORY AUTONOMIC RESPONSES TO NICOTINE
Anthony J. Yun, Kimberly A. Bazar, Patrick Y. Lee, Anthony Gerber, Stephanie M. Daniel
Medical Hypotheses Journal, November 2004
(download)

 

THE DYNAMIC RANGE OF BIOLOGIC FUNCTIONS AND VARIATION OF MANY ENVIRONMENTAL CUES MAY BE DECLINING IN THE MODERN AGE: IMPLICATIONS FOR DISEASES AND THERAPEUTICS
Anthony J. Yun, Kimberly A. Bazar, Anthony Gerber, Patrick Y. Lee, Stephanie M. Daniel
Medical Hypotheses Journal, November 2004
(download)

 

PARADOXICAL STRATEGY FOR TREATING CHRONIC DISEASES WHERE THE THERAPEUTIC EFFECT IS DERIVED FROM COMPENSATORY RESPONSE RATHER THAN DRUG EFFECT
Anthony J. Yun, Patrick Y. Lee, Kimberly A. Bazar
Medical Hypotheses Journal, September 2004
(download)

 

CAN THROMBOEMBOLISM BE THE RESULT, RATHER THAN THE INCITING CAUSE, OF ACUTE VASCULAR EVENTS SUCH AS STROKE, PULMONARY EMBOLISM, MESENTERIC ISCHEMIA, AND VENOUS THROMBOSIS?
Anthony J. Yun, Patrick Y. Lee, Kimberly A. Bazar
Medical Hypotheses Journal, August 2004
(download)

 

A NEW MECHANISM FOR DIVERTICULAR DISEASES
Anthony J. Yun, Kimberly A. Bazar, Patrick Y. Lee
Medical Hypotheses Journal, July 2004
(download)

 

SUDDEN DEATH AMONG INFANTS AND ADULTS: COMPANION DISORDERS OF MALADAPTIVE SYMPATHETIC BIAS
Anthony J. Yun, Patrick Y. Lee
Medical Hypotheses Journal, November 2003
(download)

 

Books

At PAI we want to catalyze positive change in our everyday lives. The following PAI books will teach you how to be healthier, wealthier and funnier.

Low-Stress Food: Eat your way to a low-stress life
Stephanie Daniel and Joon Yun, M.D.
Published July 2007
(purchase now)

 

Compound Thinking: The key to anticipating quantum change before it happens.
Joon Yun, M.D.
Coming Soon

 

Secrets to a Funnier You: The Art and Science of being Funny.
Chris Sams and Joon Yun, M.D.
Coming Spring 2011